Endocrine Abstracts

Vitamin D supplementation in childhood improves the achievement of peak bone mass. We investigated the effect of calcitriol on bone turnover in recent-onset type 1 diabetes (T1D). Moreover, the association between osteocalcin (OC) and metabolic control was examined.We conducted a post-hoc analysis of a double-blind, placebo-controlled study of calcitriol supplementation to preserve β-cell function. Twenty-seven recent-onset T1D, mean age 25.6...

Abscissic acid (ABA) is a hormone best known for its role in plants. We previously showed that it is released by pancreatic beta-cells upon glucose stimulation, and autocrinally enhances insulin secretion.Here we additionally report that ABA promotes glucose uptake by rat L6 myoblasts and murine 3T3-L1 cells differentiated to adipocytes, at least partly by inducing GLUT-4 translocation to the plasma membrane.To determine whether AB...